Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine

Author:

McMillan Christopher L. D.1ORCID,Choo Jovin J. Y.1ORCID,Idris Adi2ORCID,Supramaniam Aroon2,Modhiran Naphak1ORCID,Amarilla Alberto A.1,Isaacs Ariel1ORCID,Cheung Stacey T. M.1ORCID,Liang Benjamin1ORCID,Bielefeldt-Ohmann Helle134,Azuar Armira1ORCID,Acharya Dhruba2,Kelly Gabrielle2ORCID,Fernando Germain J. P.15ORCID,Landsberg Michael J.13ORCID,Khromykh Alexander A.13,Watterson Daniel13ORCID,Young Paul R.13ORCID,McMillan Nigel A. J.2ORCID,Muller David A.1ORCID

Affiliation:

1. School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.

2. Menzies Health Institute Queensland, School of Pharmacy, Anatomy and Medical Sciences, Griffith University, Gold Coast, Queensland 4222, Australia.

3. Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland 4072 and 4029, Australia.

4. School of Veterinary Science, University of Queensland Gatton Campus, Gatton, Queensland 4343, Australia.

5. Vaxxas Pty Ltd, Translational Research Institute, 37 Kent Street, Brisbane, Queensland 4102, Australia.

Abstract

Delivery of a SARS-CoV-2 vaccine to the skin of mice via microarray patches provides complete protection from challenge.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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