Regulation of telomere homeostasis and genomic stability in cancer by N 6 -adenosine methylation (m 6 A)

Author:

Lee Ji Hoon1ORCID,Hong Juyeong1ORCID,Zhang Zhao1ORCID,de la Peña Avalos Bárbara23ORCID,Proietti Cecilia J.4ORCID,Deamicis Agustina Roldán4ORCID,Guzmán G. Pablo5ORCID,Lam Hung-Ming6,Garcia Jose6,Roudier Martine P.6,Sisk Anthony E.7ORCID,De La Rosa Richard1ORCID,Vu Kevin8ORCID,Yang Mei1,Liao Yiji1,Scheirer Jessica1ORCID,Pechacek Douglas1ORCID,Yadav Pooja910,Rao Manjeet K.910ORCID,Zheng Siyuan1011,Johnson-Pais Teresa L.12ORCID,Leach Robin J.39ORCID,Elizalde Patricia V.4ORCID,Dray Eloïse23ORCID,Xu Kexin1ORCID

Affiliation:

1. Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

2. Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.

3. Mays Cancer Center, UT Health San Antonio MD Anderson, San Antonio, TX 78229, USA.

4. Laboratory of Molecular Mechanisms of Carcinogenesis and Molecular Endocrinology, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires C1428ADN, Argentina.

5. Departamento de Anatomía Patológica (BIOREN), Universidad de La Frontera, Temuco Casilla 54-D, Chile.

6. Department of Urology, University of Washington, Seattle, WA 98195, USA.

7. Department of Pathology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.

8. Department of Medical Education, Joe R. and Teresa Lozano Long School of Medicine, San Antonio, TX 78229, USA.

9. Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

10. Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

11. Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

12. Department of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX 78229, USA.

Abstract

Down-regulation of HMBOX1 via METTL3-catalyzed m 6 A causes genomic instability driven by telomere dysfunction in cancer.

Funder

National Cancer Institute

Cancer Prevention and Research Institute of Texas

Max and Minnie Tomerlin Voelcker Fund

UVA Cancer Center

Voelcker Fund Young Investigator award

Early Investigator Research Award from Department of Defense

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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