Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion-Reference-Cited by-同舟云学术

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

Published:2020-01-17 Issue:3 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Plemel Jason R.¹²³^ORCID,Stratton Jo Anne¹^ORCID,Michaels Nathan J.¹,Rawji Khalil S.¹^ORCID,Zhang Eric¹^ORCID,Sinha Sarthak⁴^ORCID,Baaklini Charbel S.²³^ORCID,Dong Yifei¹,Ho Madelene²,Thorburn Kevin⁵^ORCID,Friedman Timothy N.²^ORCID,Jawad Sana¹,Silva Claudia¹,Caprariello Andrew V.¹^ORCID,Hoghooghi Vahid¹,Yue Julie²,Jaffer Arzina⁴^ORCID,Lee Kelly²^ORCID,Kerr Bradley J.²⁶^ORCID,Midha Raj¹,Stys Peter K.¹,Biernaskie Jeff¹⁴^ORCID,Yong V. Wee¹^ORCID

Affiliation:

1. Hotchkiss Brain Institute and Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

2. Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.

3. Department of Medicine, Division of Neurology, University of Alberta, Edmonton, Alberta, Canada.

4. Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.

5. Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.

6. Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada.

Abstract

Microglia respond to white matter injury with different populations that prevent macrophage dispersion into spared tissue.

Funder

University of Alberta

Alberta Heritage Foundation for Medical Research

Canadian Institutes for Health Research

MS Society of Canada

Alberta MS Collaboration

Alberta Children’s Hospital Research Institute

University of Calgary Cummings School of Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

1. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

2. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

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5. A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

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