INSIGHT: A population-scale COVID-19 testing strategy combining point-of-care diagnosis with centralized high-throughput sequencing

Author:

Wu Qianxin1ORCID,Suo Chenqu12ORCID,Brown Tom3,Wang Tengyao4ORCID,Teichmann Sarah A.15ORCID,Bassett Andrew R.1ORCID

Affiliation:

1. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

2. Department of Paediatrics, Cambridge University Hospitals, Hills Road, Cambridge CB2 0QQ, UK.

3. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK.

4. Department of Statistical Science, University College London, 1-19 Torrington Place, London WC1E 7HB, UK.

5. Department of Physics/Cavendish Laboratory, University of Cambridge, JJ Thomson Ave., Cambridge CB3 0HE, UK.

Abstract

INSIGHT is a two-stage COVID-19 test, which combines point-of-care diagnosis with NGS, aiming to achieve population-scale testing.

Funder

Wellcome Trust Centre for Mitochondrial Research

Wellcome Trust fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. World Health Organization “Naming the coronavirus disease (COVID-19) and the virus that causes it ” 11 February 2020; www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it.

2. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

3. World Health Organization “Coronavirus disease 2019 (COVID-19) situation report −73 ” 2 April 2020; www.who.int/docs/default-source/coronaviruse/situation-reports/20200402-sitrep-73-covid-19.pdf.

4. World Health Organization “Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases ” 2 March 2020; https://apps.who.int/iris/bitstream/handle/10665/331329/WHO-COVID-19-laboratory-2020.4-eng.pdf?sequence=1&isAllowed=y.

5. Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study

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