1. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
2. Department of Paediatrics, Cambridge University Hospitals, Hills Road, Cambridge CB2 0QQ, UK.
3. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK.
4. Department of Statistical Science, University College London, 1-19 Torrington Place, London WC1E 7HB, UK.
5. Department of Physics/Cavendish Laboratory, University of Cambridge, JJ Thomson Ave., Cambridge CB3 0HE, UK.