Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle-Reference-Cited by-同舟云学术

Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle

Published:2021-02-12 Issue:7 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Lee Yool¹^ORCID,Fong Shi Yi¹^ORCID,Shon Joy¹,Zhang Shirley L.¹^ORCID,Brooks Rebekah²³^ORCID,Lahens Nicholas F.⁴^ORCID,Chen Dechun¹^ORCID,Dang Chi Van³⁵,Field Jeffrey M.⁶^ORCID,Sehgal Amita¹^ORCID

Affiliation:

1. Howard Hughes Medical Institute, Chronobiology and Sleep Institute (CSI), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Cell and Molecular Biology Graduate Group (CAMB), University of Pennsylvania, Philadelphia, PA 19104, USA.

3. The Wistar Institute, Philadelphia, PA 19104, USA.

4. Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Ludwig Institute for Cancer Research, New York, NY 10017, USA.

6. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Circadian regulation of tumors provides a basis for chemotherapy at specific times of day.

Funder

National Institutes of Health

U.S. Department of Defense

National Cancer Institute

American Council of Learned Societies

Children’s Tumor Foundation

NIH

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)