Red blood cell–derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy

Author:

Han Xiao1ORCID,Shen Shufang1ORCID,Fan Qin1,Chen Guojun2,Archibong Edikan3,Dotti Gianpietro3,Liu Zhuang1,Gu Zhen24ORCID,Wang Chao1ORCID

Affiliation:

1. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China.

2. Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

3. Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4. California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

We developed an antigen delivery system based on the nanoerythrocyte vehicle combined with anti–PD-L1 for cancer immunotherapy.

Funder

the Program for Jiangsu Specially-Appointed Professors

startup supports of Soochow University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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