Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder

Author:

Curtin Paul1,Austin Christine1ORCID,Curtin Austen1,Gennings Chris1,Arora Manish1,Tammimies Kristiina23ORCID,Willfors Charlotte23ORCID,Berggren Steve23ORCID,Siper Paige45,Rai Dheeraj6ORCID,Meyering Kristin45,Kolevzon Alexander45,Mollon Josephine7,David Anthony S.7ORCID,Lewis Glyn8ORCID,Zammit Stanley69,Heilbrun Lynne10ORCID,Palmer Raymond F.10ORCID,Wright Robert O.1,Bölte Sven23ORCID,Reichenberg Abraham1457,

Affiliation:

1. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA.

2. Center of Neurodevelopmental Disorders, Division of Neuropsychiatry, Department of Women’s and Children’s Health, Karolinska Institutet, Floor 8, Gävlegatan 22, SE-11330 Stockholm, Sweden.

3. Child and Adolescent Psychiatry, Center for Psychiatry Research, Stockholm County Council, Norra Stationsgatan 69, Plan 7, SE-11364 Stockholm, Sweden.

4. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

5. Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

6. Centre for Academic Mental Health, School of Social and Community Medicine, University of Bristol, Bristol, England.

7. Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, England.

8. Division of Psychiatry, Faculty of Brain Sciences, University College London, Maple House, London, England.

9. Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, Wales.

10. Family and Community Medicine, School of Medicine, University of Texas Health Sciences Center, San Antonio, TX 78229, USA.

Abstract

Baby tooth analysis shows that fetal and early postnatal zinc-copper metabolic rhythms predict autism risk.

Funder

National Institute of Environmental Health Sciences

Swedish Research Council

Knut and Alice Wallenberg foundation

Beatrice and Samuel A. Seaver Foundation

UK Medical Research Council and Wellcome

Innovative Medicines Initiatives Joint Undertaking

European Federation of Pharmaceutical Industries and Associations

Swedish Research Council for Health, Working Life and Welfare, Formas and VINNOVA

Stiftelsen Frimurare Barnhuset, Sunnerdahls, Handikappfond, Hjärnfonden and the Swedish Foundation for International Cooperation in Research and Higher Education

European Union’s Seventh Framework Programme

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference56 articles.

1. Fetal and postnatal metal dysregulation in autism;Arora M.;Nat. Commun.,2017

2. Estimation of autistic children by metallomics analysis;Yasuda H.;Sci. Rep.,2013

3. Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3

4. Environmental factors in autism;Grabrucker A. M.;Front. Psychiatry,2012

5. Wilson disease in children;Roberts E. A.;Handb. Clin. Neurol.,2017

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