Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis
Author:
Affiliation:
1. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
2. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
Abstract
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Link
https://www.science.org/doi/pdf/10.1126/sciadv.adg8156
Reference69 articles.
1. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
2. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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4. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
5. PINK1 is degraded through the N-end rule pathway
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