Lymphangiogenesis-inducing vaccines elicit potent and long-lasting T cell immunity against melanomas-Reference-Cited by-同舟云学术

Lymphangiogenesis-inducing vaccines elicit potent and long-lasting T cell immunity against melanomas

Published:2021-03-26 Issue:13 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sasso Maria Stella¹^ORCID,Mitrousis Nikolaos¹,Wang Yue¹,Briquez Priscilla S.¹,Hauert Sylvie¹^ORCID,Ishihara Jun¹^ORCID,Hubbell Jeffrey A.¹^ORCID,Swartz Melody A.¹²^ORCID

Affiliation:

1. Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA.

2. Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA.

Abstract

New approach for immune cell recruitment in therapeutic anticancer vaccines drives antigenically broad and long-lasting immunity.

Funder

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

1. Steady-State Antigen Scavenging, Cross-Presentation, and CD8+T Cell Priming: A New Role for Lymphatic Endothelial Cells

2. VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

3. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

4. Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation

5. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

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