Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor-Reference-Cited by-同舟云学术

Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor

Published:2021-06-11 Issue:24 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cornblath Eli J.¹²^ORCID,Li Howard L.³^ORCID,Changolkar Lakshmi³^ORCID,Zhang Bin³,Brown Hannah J.³^ORCID,Gathagan Ronald J.³,Olufemi Modupe F.³,Trojanowski John Q.³^ORCID,Bassett Danielle S.¹⁴⁵⁶⁷^ORCID,Lee Virginia M. Y.³,Henderson Michael X.⁸^ORCID

Affiliation:

1. Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Department of Electrical and Systems Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Physics and Astronomy, College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.

6. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

7. Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

8. Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, USA.

Abstract

Spread of tau pathology follows brain connectivity, is modulated by selective vulnerability, and is predicted by network analysis.

Funder

National Science Foundation

National Institutes of Health

John D. and Catherine T. MacArthur Foundation

Indian Statistical Institute

Michael J. Fox Foundation for Parkinson’s Research

Alfred P. Sloan Foundation

Paul G. Allen Family Foundation

ISI Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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