IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression-Reference-Cited by-同舟云学术

IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

Published:2020-07-31 Issue:31 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Almanan Maha¹^ORCID,Raynor Jana¹,Ogunsulire Ireti²,Malyshkina Anna¹^ORCID,Mukherjee Shibabrata¹,Hummel Sarah A.¹,Ingram Jennifer T.³,Saini Ankur¹⁴^ORCID,Xie Markus M.⁵^ORCID,Alenghat Theresa¹⁴⁶^ORCID,Way Sing Sing⁶⁷^ORCID,Deepe George S.⁵^ORCID,Divanovic Senad¹^ORCID,Singh Harinder¹⁴^ORCID,Miraldi Emily¹⁴^ORCID,Zajac Allan J.³,Dent Alexander L.⁸^ORCID,Hölscher Christoph²,Chougnet Claire¹⁴,Hildeman David A.¹⁴^ORCID

Affiliation:

1. Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

2. Division of Infection Immunology, Research Center Borstel, Borstel, Germany.

3. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

4. Center for Systems Immunology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.

5. Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

6. Center for Inflammation and Tolerance, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.

7. Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

8. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Abstract

Elevated IL-10 in aged mice suppresses immune responses and has implications for vaccine nonresponsiveness in the elderly.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

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3. Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway

4. Telomere Shortening, Inflammatory Cytokines, and Anti-Cytomegalovirus Antibody Follow Distinct Age-Associated Trajectories in Humans

5. Gender-specific association between −1082 IL-10 promoter polymorphism and longevity

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