BBB pathophysiology–independent delivery of siRNA in traumatic brain injury-Reference-Cited by-同舟云学术

BBB pathophysiology–independent delivery of siRNA in traumatic brain injury

Published:2021-01 Issue:1 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Li Wen¹²³^ORCID,Qiu Jianhua³⁴,Li Xiang-Ling¹,Aday Sezin¹²^ORCID,Zhang Jingdong⁴⁵^ORCID,Conley Grace⁴^ORCID,Xu Jun¹³^ORCID,Joseph John¹³,Lan Haoyue¹,Langer Robert²⁶^ORCID,Mannix Rebekah³⁴^ORCID,Karp Jeffrey M.¹³⁶⁷⁸^ORCID,Joshi Nitin¹²³^ORCID

Affiliation:

1. Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.

2. Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Harvard Medical School, Boston, MA 02115, USA.

4. Division of Emergency Medicine, Boston Children’s Hospital, Boston, MA 02115, USA.

5. Department of Neurosurgery, Brigham and Women’s Hospital, Boston, MA 02115, USA.

6. Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

7. Broad Institute, Cambridge, MA 02142, USA.

8. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

Abstract

We describe a nanoparticle platform for brain delivery of nucleic acid–based therapeutics to treat TBI.

Funder

National Institutes of Health

Fundação para a Ciência e a Tecnologia

Harvard Football Players Health Study

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary