Rational antibody design for undruggable targets using kinetically controlled biomolecular probes-Reference-Cited by-同舟云学术

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Rational antibody design for undruggable targets using kinetically controlled biomolecular probes

Published:2021-04-16 Issue:16 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Trkulja Carolina L.¹^ORCID,Jungholm Oscar²^ORCID,Davidson Max¹,Jardemark Kent²,Marcus Monica M.²,Hägglund Jessica¹²^ORCID,Karlsson Anders¹³,Karlsson Roger¹³^ORCID,Bruton Joseph²^ORCID,Ivarsson Niklas²,Srinivasa Sreesha P.¹^ORCID,Cavallin Alexandra²,Svensson Peder⁴^ORCID,Jeffries Gavin D. M.⁵^ORCID,Christakopoulou Maria-Nefeli²,Reymer Anna¹⁶^ORCID,Ashok Anaswara¹,Willman Gabriella¹,Papadia Daniela¹,Johnsson Emma¹^ORCID,Orwar Owe¹²^ORCID

Affiliation:

1. Oblique Therapeutics AB, SE-41346 Gothenburg, Sweden.

2. Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

3. Nanoxis Consulting AB, SE-40016 Gothenburg, Sweden.

4. Integrative Research Laboratories, SE-41346, Gothenburg, Sweden.

5. Fluicell AB, SE-431 37 Mölndal, Sweden.

6. Department of Chemistry and Molecular Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden.

Abstract

This newly developed biological probes/proteomics method yields functional antibodies targeting previously undruggable targets.

Funder

VINNOVA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference66 articles.

1. The Antibody Society (2020); www.antibodysociety.org.

2. Ion channels as therapeutic antibody targets

3. Antibodies and venom peptides: new modalities for ion channels

4. Monoclonal Antibodies Targeting Ion Channels and Their Therapeutic Potential

5. Continuous cultures of fused cells secreting antibody of predefined specificity

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent Progress in Antibody Epitope Prediction;Antibodies;2023-08-08

2. Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project;Journal of Proteome Research;2021-10-20

3. Targeting the Transcriptome Through Globally Acting Components;Frontiers in Genetics;2021-09-16

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