High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II-Reference-Cited by-同舟云学术

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

Published:2021-11-05 Issue:45 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

van Hoolwerff Marcella¹^ORCID,Rodríguez Ruiz Alejandro¹^ORCID,Bouma Marga²³^ORCID,Suchiman H. Eka D.¹^ORCID,Koning Roman I.⁴^ORCID,Jost Carolina R.⁴^ORCID,Mulder Aat A.⁴^ORCID,Freund Christian²³,Guilak Farshid⁵^ORCID,Ramos Yolande F. M.¹^ORCID,Meulenbelt Ingrid¹^ORCID

Affiliation:

1. Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands.

2. LUMC hiPSC Hotel, Leiden University Medical Center, Leiden, Netherlands.

3. Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands.

4. Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.

5. Department of Orthopedic Surgery, Washington University and Shriners Hospitals for Children, St. Louis, MO, USA.

Abstract

Fibronectin binding to collagen type II is crucial for articular chondrocytes to stay in a healthy steady state.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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