Multi-omics characterization of molecular features of gastric cancer correlated with response to neoadjuvant chemotherapy

Author:

Li Ziyu1ORCID,Gao Xiangyu1ORCID,Peng Xinxin2ORCID,May Chen Mei-Ju3ORCID,Li Zhe2ORCID,Wei Bin2,Wen Xianzi4,Wei Baoye2,Dong Yu2,Bu Zhaode1ORCID,Wu Aiwen1,Wu Qi5,Tang Lei6,Li Zhongwu7,Liu Yiqiang7,Zhang Li7ORCID,Jia Shuqin8,Zhang Lianhai1ORCID,Shan Fei1ORCID,Zhang Ji1,Wu Xiaojiang1,Ji Xin1,Ji Ke1,Wu Xiaolong1ORCID,Shi Jinyao4ORCID,Xing Xiaofang8,Wu Jianmin9ORCID,Lv Guoqing10,Shen Lin11,Ji Xuwo2ORCID,Liang Han312ORCID,Ji Jiafu1ORCID

Affiliation:

1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Cancer Center, Peking University Cancer Hospital and Institute, Beijing 100142, China.

2. Precision Scientific (Beijing) Ltd., Beijing 100085, China.

3. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

4. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), GI Cancer Translation Research Lab, Peking University Cancer Hospital and Institute, Beijing 100142, China.

5. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Endoscopy Center, Peking University Cancer Hospital and Institute, Beijing 100142, China.

6. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital and Institute, Beijing 100142, China.

7. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing 100142, China.

8. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Molecular Diagnostics, Peking University Cancer Hospital and Institute, Beijing 100142, China.

9. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Cancer Bioinformatics, Peking University Cancer Hospital and Institute, Beijing 100142, China.

10. Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.

11. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of GI Oncology, Peking University Cancer Hospital and Institute, Beijing 100142, China.

12. Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

We performed the multi-omic characterization of gastric cancer to detect key molecular features for neoadjuvant chemotherapy.

Funder

National Science Foundation Fund of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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