Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn’s disease-Reference-Cited by-同舟云学术

Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn’s disease

Published:2021-11-05 Issue:45 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Haq Sabah¹²^ORCID,Wang Huaqing¹²,Grondin Jensine¹²^ORCID,Banskota Suhrid¹²^ORCID,Marshall John K.¹³,Khan Irfan I.²⁴,Chauhan Usha³⁵^ORCID,Cote Francine⁶,Kwon Yun Han¹²^ORCID,Philpott Dana⁷^ORCID,Brumell John H.⁸⁹^ORCID,Surette Michael¹³¹⁰,Steinberg Gregory R.³¹⁰¹¹^ORCID,Khan Waliul I.¹²⁵¹¹^ORCID

Affiliation:

1. Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

2. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

3. Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

4. Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

5. Hamilton Health Sciences, Hamilton, Ontario, Canada.

6. Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France.

7. Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

8. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

9. Ontario and Cell Biology Program, Hospital for Sick Children, Toronto, Ontario, Canada.

10. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

11. Centre for Metabolism Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.

Abstract

Elevated gut serotonin inhibits autophagy via mTOR promoting a disrupted microbiota and enhanced susceptibility to colitis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference71 articles.

1. Host–microbiota interactions in inflammatory bowel disease

2. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

3. Genome-wide Association Scanning Highlights Two Autophagy Genes,ATG16L1andIRGM, as Being Significantly Associated with Crohn’s Disease

4. New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

5. Autophagy: roles in intestinal mucosal homeostasis and inflammation

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