LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation-Reference-Cited by-同舟云学术

LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation

Published:2021-03-26 Issue:13 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wang Ruijie¹^ORCID,Cao Leixi¹^ORCID,Thorne Rick Francis¹²^ORCID,Zhang Xu Dong¹³^ORCID,Li Jinming¹^ORCID,Shao Fengmin¹^ORCID,Zhang Lirong¹^ORCID,Wu Mian¹⁴⁵^ORCID

Affiliation:

1. Translational Research Institute, Henan Provincial People’s Hospital, Academy of Medical Science, Zhengzhou University, Zhengzhou 450053, China.

2. School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2258, Australia.

3. School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.

4. School of Clinical Medicine, Henan University, Zhengzhou 450003, China.

5. CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Centre for Excellence in Molecular Cell Science, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230027, China.

Abstract

When glutamine is limiting, lncRNA GIRGL inhibits glutaminase activity through phase separation to enable cancer cell survival.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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