A unified 3D map of microscopic architecture and MRI of the human brain-Reference-Cited by-同舟云学术

A unified 3D map of microscopic architecture and MRI of the human brain

Published:2022-04-29 Issue:17 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Alkemade Anneke¹^ORCID,Bazin Pierre-Louis¹²³^ORCID,Balesar Rawien⁴,Pine Kerrin²^ORCID,Kirilina Evgeniya²⁵^ORCID,Möller Harald E.⁶^ORCID,Trampel Robert²^ORCID,Kros Johan M.⁷,Keuken Max C.¹^ORCID,Bleys Ronald L. A. W.⁸,Swaab Dick F.⁴^ORCID,Herrler Andreas⁹,Weiskopf Nikolaus²¹⁰¹¹^ORCID,Forstmann Birte U.¹^ORCID

Affiliation:

1. Integrative Model-Based Neuroscience Research Unit, University of Amsterdam, Amsterdam, Netherlands.

2. Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

3. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

4. Department of Neuropsychiatric disorders, Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands.

5. Neurocomputation and Neuroimaging Unit, Department of Psychology and Educational Science, Free University Berlin, Habelschwerdter Allee 45, Berlin 14195, Germany.

6. NMR Methods Development Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

7. Department of Pathology, Erasmus Medical Center, Rotterdam, Netherlands.

8. Department of Anatomy, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

9. Department of Anatomy and Embryology, Maastricht University, Maastricht, Netherlands.

10. Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences, Leipzig University, Linnéstraße 5, Leipzig 04103, Germany.

11. Wellcome Centre for Human Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3AR, UK.

Abstract

We present the first three-dimensional (3D) concordance maps of cyto- and fiber architecture of the human brain, combining histology, immunohistochemistry, and 7-T quantitative magnetic resonance imaging (MRI), in two individual specimens. These 3D maps each integrate data from approximately 800 microscopy sections per brain, showing neuronal and glial cell bodies, nerve fibers, and interneuronal populations, as well as ultrahigh-field quantitative MRI, all coaligned at the 200-μm scale to the stacked blockface images obtained during sectioning. These unprecedented 3D multimodal datasets are shared without any restrictions and provide a unique resource for the joint study of cell and fiber architecture of the brain, detailed anatomical atlasing, or modeling of the microscopic underpinnings of MRI contrasts.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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