Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits-Reference-Cited by-同舟云学术

Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits

Published:2020-08-14 Issue:33 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Banks Gareth T.¹^ORCID,Guillaumin Mathilde C. C.²^ORCID,Heise Ines¹^ORCID,Lau Petrina¹^ORCID,Yin Minghui¹^ORCID,Bourbia Nora¹^ORCID,Aguilar Carlos¹,Bowl Michael R.¹^ORCID,Esapa Chris¹,Brown Laurence A.²^ORCID,Hasan Sibah²,Tagliatti Erica³^ORCID,Nicholson Elizabeth³^ORCID,Bains Rasneer Sonia⁴^ORCID,Wells Sara⁴^ORCID,Vyazovskiy Vladyslav V.²⁵^ORCID,Volynski Kirill³^ORCID,Peirson Stuart N.²^ORCID,Nolan Patrick M.¹^ORCID

Affiliation:

1. Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science and Innovation Campus, Oxfordshire, UK.

2. Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

3. UCL Queen Square Institute of Neurology, University College London, London, UK.

4. Mary Lyon Centre, MRC Harwell Institute, Harwell Science and Innovation Campus, Oxfordshire, UK.

5. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

Abstract

A noninvasive sleep screen uncovers a Vamp2 mouse mutation with synaptic deficits underlying substantial sleep disturbances.

Funder

Medical Research Council

Biotechnology and Biological Sciences Research Council

John Fell Fund, University of Oxford

Wellcome Trust Centre for Mitochondrial Research

ERUK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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