A cytoskeletal function for PBRM1 reading methylated microtubules

Author:

Karki Menuka1ORCID,Jangid Rahul K.1ORCID,Anish Ramakrishnan2ORCID,Seervai Riyad N. H.134ORCID,Bertocchio Jean-Philippe15ORCID,Hotta Takashi6ORCID,Msaouel Pavlos5ORCID,Jung Sung Yun2ORCID,Grimm Sandra L.7ORCID,Coarfa Cristian138ORCID,Weissman Bernard E.9ORCID,Ohi Ryoma6,Verhey Kristen J.6,Hodges H. Courtney13ORCID,Burggren Warren10ORCID,Dere Ruhee13ORCID,Park In Young13ORCID,Prasad B. V. Venkataram2ORCID,Rathmell W. Kimryn11ORCID,Walker Cheryl L.13812ORCID,Tripathi Durga N.13ORCID

Affiliation:

1. Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030, USA.

2. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

3. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

4. Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030, USA.

5. Department of Genitourinary Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA.

6. Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

7. Advanced Technology Cores, Baylor College of Medicine, Houston, TX 77030, USA.

8. Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

9. Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.

10. Department of Biological Sciences, University of North Texas, Denton, TX 76201, USA.

11. Vanderbilt-Ingram Cancer Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

12. Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Methyl marks made by the epigenetic writer SETD2 recruit the epigenetic reader PBRM1 to spindle microtubules during mitosis.

Funder

National Institutes of Health

National Cancer Institute

Cancer Prevention and Research Institute of Texas

Welch Foundation

John Templeton Foundation

U.S. Department of Defense

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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