MCART1/SLC25A51 is required for mitochondrial NAD transport-Reference-Cited by-同舟云学术

MCART1/SLC25A51 is required for mitochondrial NAD transport

Published:2020-10-23 Issue:43 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kory Nora¹²³⁴^ORCID,uit de Bos Jelmi¹^ORCID,van der Rijt Sanne¹^ORCID,Jankovic Nevena¹^ORCID,Güra Miriam¹,Arp Nicholas¹^ORCID,Pena Izabella A.¹^ORCID,Prakash Gyan¹^ORCID,Chan Sze Ham¹^ORCID,Kunchok Tenzin¹^ORCID,Lewis Caroline A.¹^ORCID,Sabatini David M.¹²³⁴^ORCID

Affiliation:

1. Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.

2. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

4. Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge MA 02142, USA.

Abstract

We demystify how mitochondria obtain NAD, revealing that MCART1 / SCL25A51 is required for NAD transport into mitochondria.

Funder

U.S. Department of Defense

Howard Hughes Medical Institute

National Cancer Institute

Damon Runyon Cancer Research Foundation

St. Baldrick’s Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject