A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad-Reference-Cited by-同舟云学术

A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad

Published:2018-04-06 Issue:4 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kumar Prashasti¹^ORCID,Serpersu Engin H.¹²³^ORCID,Cuneo Matthew J.⁴^ORCID

Affiliation:

1. University of Tennessee–Oak Ridge National Laboratory Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, TN 37996, USA.

2. National Science Foundation, 2415 Eisenhower Avenue, Alexandria, VA 22314, USA.

3. Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.

4. Neutron Sciences Directorate, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.

Abstract

Substrate participation in forming a catalytic triad aids in antibiotic resistance by aminoglycoside N3 -acetyltransferases.

Funder

National Science Foundation

U.S. Department of Energy

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

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2. Inactivation of Antibiotics and the Dissemination of Resistance Genes

3. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes;Shaw K. J.;Microbiol. Rev.,1993

4. Crystal structure of an aminoglycoside 6′-N-acetyltransferase: Defining the GCN5-related N-acetyltransferase superfamily fold;Wybenga-Groot L. E.;Structure,1999

5. GCN5-related N-acetyltransferases: A structural overview;Dyda F.;Annu. Rev. Biophys. Biomol. Struct.,2000

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