CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation-Reference-Cited by-同舟云学术

CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation

Published:2020-05-22 Issue:21 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sun Wujin¹²³⁴^ORCID,Wang Jinqiang¹²³^ORCID,Hu Quanyin¹²³,Zhou Xingwu¹²⁵,Khademhosseini Ali¹²⁴⁵⁶^ORCID,Gu Zhen¹²³⁴⁷^ORCID

Affiliation:

1. Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

2. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.

3. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.

4. Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

5. Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

6. Department of Radiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

7. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

A DNA-based bioresponsive nanoformulation delivers the CRISPR-Cas12a to hepatocytes for regulating serum cholesterol.

Funder

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

Start-up packages of UCLA and UNC/NC State

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference56 articles.

1. CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery

2. In vivo neuronal gene editing via CRISPR–Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer’s disease

3. CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions

4. Therapeutic genome editing: prospects and challenges

5. Development and Applications of CRISPR-Cas9 for Genome Engineering

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