Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function

Author:

Brown Matthew R.1ORCID,Sen Satish K.1,Mazzone Amelia23ORCID,Her Tracy K.1ORCID,Xiong Yuning34,Lee Jeong-Heon234ORCID,Javeed Naureen1ORCID,Colwell Christopher S.5ORCID,Rakshit Kuntol1,LeBrasseur Nathan K.6ORCID,Gaspar-Maia Alexandre23ORCID,Ordog Tamas137ORCID,Matveyenko Aleksey V.18ORCID

Affiliation:

1. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

2. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

3. Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.

4. Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

5. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

6. Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.

7. Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

8. Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Abstract

Time-restricted feeding improves glucose homeostasis through epigenetic control of pancreatic β cell function.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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