Interfering MSN-NONO complex–activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer

Author:

Qin Yuanyuan12ORCID,Chen Weilong12,Jiang Guojuan1,Zhou Lei12ORCID,Yang Xiaoli1,Li Hongqi3,He Xueyan1,Wang Han-lin45ORCID,Zhou Yu-bo5,Huang Shenglin1,Liu Suling1ORCID

Affiliation:

1. Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Key Laboratory of Breast Cancer in Shanghai, Innovation Center for Cell Signaling Network, Cancer Institutes, Fudan University, Shanghai 200032, China.

2. School of Life Sciences, CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, Hefei, Anhui 230027, China.

3. Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

4. School of Life Science and Technology, Shanghai Tech University, Shanghai 201203, China.

5. National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Abstract

MSN and NONO and their interaction-activated CREB signaling pathway may be new targets for the treatment and prognosis of TNBC.

Funder

The National Key Research and Development Program of China

NSFC Grant

Fudan University Research Foundation

Research Foundation of the Fudan University Shanghai Cancer Center

the MOST grant

Fudan-SIMM Joint Research Fund

Program for Outstanding Medical Academic Leader

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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