Affiliation:
1. Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Aachen, Germany.
2. Max Planck Institute for Chemical Energy Conversion, Mülheim an der Ruhr, Germany.
Abstract
The carboxylation of nonactivated C─H bonds provides an attractive yet hitherto largely elusive chemical process to synthesize carboxylic acids by incorporation of CO
2
into the chemical value chain. Here, we report on the realization of such a reaction using simple and nonactivated arenes as starting materials. A computationally designed Pd(II) complex acts as organometallic single-component catalyst, and apart from a base, necessary for thermodynamic stabilization of the intermediates, no other additives or coreagents are required. Turnover numbers up to 10
2
and high regioselectivities are achieved. The potential of this catalytic reaction for “green chemistry” is demonstrated by the synthesis of veratric acid, an intermediate for pharmaceutical production, from CO
2
and veratrol.
Publisher
American Association for the Advancement of Science (AAAS)
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