Low-flow intussusception and metastable VEGFR2 signaling launch angiogenesis in ischemic muscle

Author:

Arpino John-Michael12ORCID,Yin Hao1ORCID,Prescott Emma K.12ORCID,Staples Sabrina C. R.12ORCID,Nong Zengxuan1,Li Fuyan1,Chevalier Jacqueline12ORCID,Balint Brittany12ORCID,O’Neil Caroline1,Mortuza Rokhsana1,Milkovich Stephanie12,Lee Jason J.123ORCID,Lorusso Daniel1ORCID,Sandig Martin4ORCID,Hamilton Douglas W.4,Holdsworth David W.12ORCID,Poepping Tamie L.5ORCID,Ellis Christopher G.123ORCID,Pickering J. Geoffrey1236ORCID

Affiliation:

1. Robarts Research Institute, Western University, London, Canada.

2. Department of Medical Biophysics, Western University, London, Canada.

3. Department of Medicine, Western University, London, Canada.

4. Department of Anatomy and Cell Biology, Western University, London, Canada.

5. Department of Physics and Astronomy, Western University, London, Canada.

6. Department of Biochemistry, Western University, London, Canada.

Abstract

The vasculature in ischemic muscle is rebuilt by the splitting of primordial vessels, led by VEGFR2-metastable endothelial cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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