Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines

Author:

Dirisala Anjaneyulu1ORCID,Uchida Satoshi12ORCID,Toh Kazuko1ORCID,Li Junjie1ORCID,Osawa Shigehito13ORCID,Tockary Theofilus A.1ORCID,Liu Xueying1,Abbasi Saed1ORCID,Hayashi Kotaro1ORCID,Mochida Yuki1ORCID,Fukushima Shigeto1,Kinoh Hiroaki1ORCID,Osada Kensuke4ORCID,Kataoka Kazunori15ORCID

Affiliation:

1. Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan.

2. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

3. Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.

4. National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

5. Institute for Future Initiatives, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Abstract

Transient in situ stealth coating of liver sinusoids using two-armed PEG relocates nanomedicines from the liver to their targets.

Funder

Japan Agency for Medical Research and Development

Japan Science and Technology Agency

Ministry of Education, Culture, Sports, Science and Technology, Japan

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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