A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells-Reference-Cited by-同舟云学术

A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells

Published:2020-11-20 Issue:47 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yang Kisuk¹²³⁴⁵^ORCID,Lee Miseon⁶⁷^ORCID,Jones Peter Anthony¹²³^ORCID,Liu Sophie S.¹²^ORCID,Zhou Angela¹²^ORCID,Xu Jun¹²^ORCID,Sreekanth Vedagopuram⁶⁷^ORCID,Wu Jamie L. Y.¹²^ORCID,Vo Lillian¹²^ORCID,Lee Eunjee A.¹²³^ORCID,Pop Ramona⁸,Lee Yuhan¹²³^ORCID,Wagner Bridget K.⁶,Melton Douglas A.⁸,Choudhary Amit⁶⁷⁹¹⁰^ORCID,Karp Jeffrey M.¹²³⁴^ORCID

Affiliation:

1. Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

3. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

4. Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

5. David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02142, USA.

6. Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

7. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

8. Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

9. Divisions of Renal Medicine and Engineering, Brigham and Women’s Hospital, Boston, MA 02115, USA.

10. Chemical Biology Program, Harvard University, Cambridge, MA 02138, USA.

Abstract

Interrogating zinc-binding prodrug in a 3D-reconstructed β cell environment.

Funder

National Institutes of Health

Burroughs Wellcome Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference61 articles.

1. Relationship between β-cell mass and diabetes onset

2. Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans

3. Five-Year Follow-Up After Clinical Islet Transplantation

4. Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets

5. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

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