The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin-Reference-Cited by-同舟云学术

The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin

Author:

Li Yang¹^ORCID,Sheftic Sarah R.¹^ORCID,Grigoriu Simina²,Schwieters Charles D.³^ORCID,Page Rebecca¹^ORCID,Peti Wolfgang¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of Arizona, 1041 E. Lowell St., Tucson, AZ 85721, USA.

2. Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 185 Meeting St., Providence, RI 02912, USA.

3. Imaging Sciences Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

This study shows how RCAN1, a key protein in Down syndrome and Alzheimer’s disease, modulates CN function.

Funder

National Institute of General Medical Sciences

National Institute of Neurological Disorders and Stroke

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference51 articles.

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