Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

Author:

Ochiai Hiroshi12ORCID,Hayashi Tetsutaro3ORCID,Umeda Mana3ORCID,Yoshimura Mika3ORCID,Harada Akihito4,Shimizu Yukiko5,Nakano Kenta5ORCID,Saitoh Noriko6,Liu Zhe7ORCID,Yamamoto Takashi12ORCID,Okamura Tadashi58,Ohkawa Yasuyuki4ORCID,Kimura Hiroshi9ORCID,Nikaido Itoshi310ORCID

Affiliation:

1. Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-0046, Japan.

2. Genome Editing Innovation Center, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-0046, Japan.

3. Laboratory for Bioinformatics Research, RIKEN BDR, Wako, Saitama 351-0198, Japan.

4. Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Fukuoka 812-0054, Japan.

5. Department of Animal Medicine, National Center for Global Health and Medicine (NCGM), Tokyo 812-0054, Japan.

6. Division of Cancer Biology, The Cancer Institute of JFCR, Tokyo 135-8550, Japan.

7. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

8. Section of Animal Models, Department of Infectious Diseases, National Center for Global Health and Medicine (NCGM), Tokyo 812-0054, Japan.

9. Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8503, Japan.

10. Bioinformatics Course, Master’s/Doctoral Program in Life Science Innovation (T-LSI), School of Integrative and Global Majors (SIGMA), University of Tsukuba, Wako 351-0198, Japan.

Abstract

The kinetic properties of transcriptional bursting were comprehensively analyzed in mouse embryonic stem cells.

Funder

Core Research for Evolutional Science and Technology, Japan Science and Technology Agency

Precursory Research for Embryonic Science and Technology

Grants-in-Aid for Scientific Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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