Evolutionarily conserved sequence motif analysis guides development of chemically defined hydrogels for therapeutic vascularization

Author:

Jia Jia12ORCID,Jeon Eun Je34ORCID,Li Mei15,Richards Dylan J.12,Lee Soojin67ORCID,Jung Youngmee78ORCID,Barrs Ryan W.12ORCID,Coyle Robert12,Li Xiaoyang910,Chou James C.9ORCID,Yost Michael J.11,Gerecht Sharon12,Cho Seung-Woo31314ORCID,Mei Ying12ORCID

Affiliation:

1. Bioengineering Department, Clemson University, Clemson, SC, USA.

2. Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.

3. Department of Biotechnology, Yonsei University, Seoul, Republic of Korea.

4. Department of Biomaterials Science and Engineering, Yonsei University, Seoul, Republic of Korea.

5. Department of Cardiology, Medical University of South Carolina, Charleston, SC, USA.

6. Program in Nanoscience and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.

7. Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.

8. Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.

9. Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA.

10. Ocean University of China, School of Medicine and Pharmacy, Qingdao, Shandong, China.

11. Department of Surgery, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.

12. Department of Chemical and Biomolecular Engineering, The Institute for NanoBioTechnology, and Johns Hopkins Physical Sciences–Oncology Center, The Johns Hopkins University, Baltimore, MD, USA.

13. Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea.

14. Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul, Republic of Korea.

Abstract

Motif analysis on evolutionarily conserved regions in laminin enabled the discovery of novel ligands for hydrogel development.

Funder

National Science Foundation

National Institutes of Health

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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