Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation

Author:

De Silva Angele M.1ORCID,Manville Rían W.1ORCID,Abbott Geoffrey W.1ORCID

Affiliation:

1. Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, USA.

Abstract

Analysis of a leaf extract used in African folk medicine reveals a high-affinity K + channel agonist and its binding site.

Funder

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

1. World Health Organization The World Medicines Situation (World Health Organization 2004); http://apps.who.int/medicinedocs/pdf/s6160e/s6160e.pdf.

2. Ethnobotanical studies of some medicinal plants from Lagos State of Nigeria;Adekunle A. A.;Niger. J. Bot.,2001

3. H. M. Burkhill The Useful Plants of West Tropical Africa . (Royal Botanic Gardens Kew 1994) vol. 2 pp. 636.

4. Antifungal property and phytochemical screening of the crude extracts of Funtumia elastica and Mallotus oppositifolius;Adekunle A. A.;West Indian Med. J.,2006

5. The natural plant product rottlerin activates Kv7.1/KCNE1 channels;Matschke V.;Cell. Physiol. Biochem.,2016

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