Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal

Author:

Svensson Mattias N. D.12ORCID,Zoccheddu Martina1,Yang Shen1ORCID,Nygaard Gyrid1,Secchi Christian123ORCID,Doody Karen M.2,Slowikowski Kamil45678,Mizoguchi Fumitaka49ORCID,Humby Frances10ORCID,Hands Rebecca10ORCID,Santelli Eugenio12ORCID,Sacchetti Cristiano12,Wakabayashi Kuninobu11,Wu Dennis J.1,Barback Christopher1213,Ai Rizi14ORCID,Wang Wei14ORCID,Sims Gary P.15,Mydel Piotr1617ORCID,Kasama Tsuyoshi11ORCID,Boyle David L.1ORCID,Galimi Francesco3ORCID,Vera David1213ORCID,Tremblay Michel L.181920,Raychaudhuri Soumya456721ORCID,Brenner Michael B.4ORCID,Firestein Gary S.1ORCID,Pitzalis Costantino10ORCID,Ekwall Anna-Karin H.2223ORCID,Stanford Stephanie M.12,Bottini Nunzio12ORCID

Affiliation:

1. Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, La Jolla, CA 92093, USA.

2. Division of Cellular Biology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

3. Department of Biomedical Sciences, National Institute of Biostructures and Biosystems, University of Sassari Medical School, 07100 Sassari, Italy.

4. Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

5. Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

6. Partners HealthCare Personalized Medicine, Boston, MA 02115, USA.

7. Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute and Harvard University, Cambridge, MA 02138, USA.

8. Bioinformatics and Integrative Genomics, Harvard University, Cambridge, MA 02138, USA.

9. Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8519, Japan.

10. Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

11. Division of Rheumatology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

12. Department of Radiology, University of California, La Jolla, CA 92093, USA.

13. UCSD Molecular Imaging Program, University of California, La Jolla, CA 92093, USA.

14. Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.

15. Respiratory, Inflammation and Autoimmunity, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.

16. Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, The Laboratory Building, 5th Floor, 5021 Bergen, Norway.

17. Department of Microbiology, Jagiellonian University, Kraków, Poland.

18. Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A3, Canada.

19. Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.

20. Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Québec H3A 1A3, Canada.

21. Rheumatology Unit, Karolinska Institutet, Stockholm S-171 76, Sweden.

22. Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

23. Centre for Bone and Arthritis Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Abstract

PTPRS-targeted FLS-directed therapy synergizes with TNF inhibition in therapy of arthritis.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Congressionally Directed Medical Research Programs

Arthritis National Research Foundation

MedImmune

Sahlgrenska Universitetssjukhuset

Sahlgrenska Akademin

Stiftelsen Professor Nanna Svartz Fond

Swedish Rheumatism Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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