Zika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis-Reference-Cited by-同舟云学术

Zika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis

Published:2019-10-04 Issue:10 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zhou Jia¹^ORCID,Chi Xiaojing¹^ORCID,Cheng Min¹,Huang Xingyao²^ORCID,Liu Xiuying¹,Fan Jingjing¹,Xu Hua¹,Lin Tianli¹,Shi Lei³,Qin Chengfeng²^ORCID,Yang Wei¹^ORCID

Affiliation:

1. NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

2. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.

3. The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Abstract

Both the endothelial transporter Mfsd2a and docosahexaenoic acid uptake are disrupted in Zika virus–induced microcephaly models.

Funder

National Science and Technology Major Project

National Natural Science Foundation of China grants

CAMS Initiative for Innovative Medicine Grant

National Basic Research Program of China Grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference21 articles.