Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma

Author:

Stepanov Alexey V.1ORCID,Markov Oleg V.2,Chernikov Ivan V.2,Gladkikh Daniil V.2ORCID,Zhang Hongkai34,Jones Teresa3,Sen’kova Alexandra V.2,Chernolovskaya Elena L.2,Zenkova Marina A.2,Kalinin Roman S.1ORCID,Rubtsova Maria P.5,Meleshko Alexander N.6ORCID,Genkin Dmitry D.7,Belogurov Alexey A.1,Xie Jia3ORCID,Gabibov Alexander G.1ORCID,Lerner Richard A.3ORCID

Affiliation:

1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997 Moscow V-437, Russian Federation.

2. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 8, 630090 Novosibirsk, Russian Federation.

3. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road MB-10, La Jolla, CA 92037, USA.

4. State Key Laboratory of Medicinal Chemical Biology, Nankai University, 38 Tongyan Road, Tianjin 300350, China.

5. Chemistry Department, M.V. Lomonosov Moscow State University, Lenin Hills, 1, bld. 3, 119991 Moscow, Russian Federation.

6. Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.

7. OJSC Pharmsynthez, 197110 St. Petersburg, Russian Federation.

Abstract

After decades of nonspecific lymphoma therapy, personalized approaches such as described here are on the horizon.

Funder

Russian Scientific Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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