A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity-Reference-Cited by-同舟云学术

A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity

Published:2018-11-02 Issue:11 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cornett Evan M.¹^ORCID,Dickson Bradley M.¹,Krajewski Krzysztof²,Spellmon Nicholas³,Umstead Andrew⁴,Vaughan Robert M.¹^ORCID,Shaw Kevin M.¹,Versluis Philip P.¹,Cowles Martis W.⁵^ORCID,Brunzelle Joseph⁶,Yang Zhe³,Vega Irving E.⁴,Sun Zu-Wen⁵,Rothbart Scott B.¹^ORCID

Affiliation:

1. Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

2. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Department of Microbiology, Immunology, and Biochemistry, Wayne State University School of Medicine, Detroit, MI 48201, USA.

4. Department of Translational Science and Molecular Medicine and Integrated Mass Spectrometry Unit, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA.

5. EpiCypher Inc., Research Triangle Park, NC 27709, USA.

6. Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA.

Abstract

Mapping lysine methyltransferase substrate selectivity reveals gaps in the proteome-wide curation of lysine methylomes.

Funder

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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