PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway-Reference-Cited by-同舟云学术

PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway

Published:2021-11-05 Issue:45 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Mirzaei Reza¹²^ORCID,Gordon Ashley¹²^ORCID,Zemp Franz J.³⁴^ORCID,Kumar Mehul⁴⁵,Sarkar Susobhan¹²^ORCID,Luchman H. Artee²⁴,Bellail Anita C.⁶^ORCID,Hao Chunhai⁶^ORCID,Mahoney Douglas J.³⁴⁷⁸,Dunn Jeff F.¹²⁹^ORCID,Bose Pinaki²⁴⁵¹⁰,Yong V. Wee¹²⁵^ORCID

Affiliation:

1. Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

2. Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

3. Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada.

4. Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.

5. Department of Oncology, University of Calgary, Calgary, Alberta, Canada.

6. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

7. Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.

8. Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.

9. Department of Radiology, University of Calgary, Calgary, Alberta, Canada.

10. Department of Surgery, University of Calgary, Calgary, Alberta, Canada.

Abstract

PD-1 on glioblastoma cells promotes brain tumor growth, and therapeutic antibodies cannot suppress its proliferative effects.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

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4. Identification of human brain tumour initiating cells

5. Overcoming therapeutic resistance in glioblastoma: the way forward

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