Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response-Reference-Cited by-同舟云学术

Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response

Published:2021-03-26 Issue:13 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ma Dapeng¹^ORCID,Yang Min¹^ORCID,Wang Qiushi²^ORCID,Sun Caiyu¹^ORCID,Shi Hongbiao³^ORCID,Jing Weiqiang⁴^ORCID,Bi Yuxuan⁵^ORCID,Shen Xuecheng¹^ORCID,Ma Xiaomin¹^ORCID,Qin Zhenzhi¹^ORCID,Lin Yueke¹^ORCID,Zhu Lihui¹⁶^ORCID,Zhao Yunxue⁵^ORCID,Cheng Yeping¹^ORCID,Han Lihui¹^ORCID

Affiliation:

1. Shandong Provincial Key Laboratory of Infection and Immunology, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

2. Department of Geriatric Gastroenterology, Qilu Hospital, Shandong University, Jinan 250012, China.

3. Key Laboratory for Experimental Teratology, Ministry of Education and Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

4. Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

5. Department of Pharmacology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

6. Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.

Abstract

PRMT5 directly induces methylation of cGAS and inhibits cGAS-mediated antiviral immunity.

Funder

National Natural Science Foundation of China

the Major Innovation Project of Shandong Province

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference51 articles.

1. Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

2. Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

3. Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

4. TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

5. Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

Cited by 52 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unconventional posttranslational modification in innate immunity;Cellular and Molecular Life Sciences;2024-07-06

2. Targeting protein condensation in cGAS‐STING signaling pathway;BioEssays;2024-07-04

3. A PRMT5-ZNF326 axis mediates innate immune activation upon replication stress;Science Advances;2024-06-07

4. The cGAS-Ku80 complex regulates the balance between two end joining subpathways;Cell Death & Differentiation;2024-04-25

5. The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges;Medical Review;2024-04-15