A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance

Author:

Rossetti Giulia123ORCID,Ermer Judith A.123ORCID,Stentenbach Maike123ORCID,Siira Stefan J.123ORCID,Richman Tara R.123,Milenkovic Dusanka4ORCID,Perks Kara L.123,Hughes Laetitia A.123ORCID,Jamieson Emma5ORCID,Xiafukaiti Gulibaikelamu6ORCID,Ward Natalie C.7ORCID,Takahashi Satoru6ORCID,Gray Nicola8ORCID,Viola Helena M.9ORCID,Hool Livia C.910ORCID,Rackham Oliver12111213ORCID,Filipovska Aleksandra1231314ORCID

Affiliation:

1. Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia.

2. ARC Centre of Excellence in Synthetic Biology, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.

3. Centre for Medical Research, The University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.

4. Max Planck Institute for Biology of Ageing, D-50931 Cologne, Germany.

5. Faculty of Health and Medical Sciences, Medical School, The Rural Clinical School of Western Australia, The University of Western Australia, Bunbury, Western Australia 6230, Australia.

6. Department of Anatomy and Embryology, Faculty of Medicine, Laboratory Animal Resource Center (LARC), and Transborder Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

7. Dobney Hypertension Centre, Medical School, The University of Western Australia, Perth, Western Australia, Australia.

8. Australian National Phenome Centre, Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.

9. School of Human Sciences (Physiology), The University of Western Australia, Crawley, Western Australia 6009, Australia.

10. Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, New South Wales 2010, Australia.

11. Curtin Medical School, Curtin University, Bentley, Western Australia 6102, Australia.

12. Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia 6102, Australia.

13. Telethon Kids Institute, Northern Entrance, Perth Children’s Hospital, 15 Hospital Avenue, Nedlands, Western Australia, Australia.

14. School of Molecular Sciences, The University of Western Australia, Crawley, Western Australia 6009, Australia.

Abstract

A variant in an RNA processing enzyme predisposes to insulin resistance by reducing calcium release and insulin secretion.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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