Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice

Author:

Brown Richard J. P.12ORCID,Tegtmeyer Birthe2ORCID,Sheldon Julie2,Khera Tanvi23ORCID,Anggakusuma 24,Todt Daniel256ORCID,Vieyres Gabrielle27ORCID,Weller Romy2,Joecks Sebastian2ORCID,Zhang Yudi2,Sake Svenja2,Bankwitz Dorothea2,Welsch Kathrin2,Ginkel Corinne2ORCID,Engelmann Michael25,Gerold Gisa89ORCID,Steinmann Eike25,Yuan Qinggong1011,Ott Michael1011,Vondran Florian W. R.1213,Krey Thomas1314151617ORCID,Ströh Luisa J.14ORCID,Miskey Csaba18ORCID,Ivics Zoltán18ORCID,Herder Vanessa19ORCID,Baumgärtner Wolfgang19,Lauber Chris220,Seifert Michael20ORCID,Tarr Alexander W.2122,McClure C. Patrick2122ORCID,Randall Glenn23ORCID,Baktash Yasmine24ORCID,Ploss Alexander25ORCID,Thi Viet Loan Dao2627ORCID,Michailidis Eleftherios27ORCID,Saeed Mohsan2628,Verhoye Lieven29,Meuleman Philip29ORCID,Goedecke Natascha30ORCID,Wirth Dagmar3031ORCID,Rice Charles M.26,Pietschmann Thomas21315ORCID

Affiliation:

1. Division of Veterinary Medicine, Paul Ehrlich Institute, 63225 Langen, Germany.

2. Institute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.

3. Department of Gastroenterology and Hepatology, Faculty of Medicine, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

4. Department of Research and Development, uniQure Biopharma, BV, Amsterdam, Netherlands.

5. Ruhr University Bochum, Faculty of Medicine, Department for Molecular and Medical Virology, Bochum, Germany.

6. European Virus Bioinformatics Center (EVBC), 07743 Jena, Germany.

7. Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.

8. Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany.

9. Department of Clinical Microbiology, Virology and Wallenberg Center for Molecular Medicine (WCMM), Umeå University, 901 85 Umeå, Sweden.

10. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.

11. Twincore Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.

12. Department of General, Visceral, and Transplant Surgery, Hannover Medical School, 30625 Hannover, Germany.

13. German Centre for Infection Research (DZIF), Hannover-Braunschweig Site, Braunschweig, Germany.

14. Institute of Virology, Hannover Medical School, Hannover, Germany.

15. Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

16. Center of Structural and Cell Biology in Medicine, Institute of Biochemistry, University of Luebeck, Luebeck, Germany.

17. Centre for Structural Systems Biology (CSSB), Hamburg, Germany.

18. Division of Medical Biotechnology, Paul Ehrlich Institute, 63225 Langen, Germany.

19. Department of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.

20. Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

21. School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.

22. School of Life Sciences and NIHR Nottingham BRC, University of Nottingham, Nottingham, UK.

23. Department of Microbiology, The University of Chicago, Chicago, IL 60439, USA.

24. Instituto de Biología Integrativa de Sistemas (I2SysBio), Parc Científic de Barcelona, Carrer del Catedràtic Agustín Escardino 9, 46980 Paterna, Valencia, Spain.

25. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

26. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.

27. Schaller Research Group at Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Cluster of Excellence CellNetworks, Heidelberg, Germany.

28. Department of Biochemistry, Boston University School of Medicine, National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA.

29. Laboratory of Liver Infectious Diseases, Ghent University, Ghent, Belgium.

30. Helmholtz Centre for Infection Research, Division Model Systems for Infection and Immunity, Inhoffenstraße 7, 38124 Braunschweig, Germany.

31. Department of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.

Abstract

Two transmembrane proteins cooperate to block infection of murine hepatocytes by human-tropic hepatitis C virus.

Funder

H2020 European Research Council

Bundesministerium für Gesundheit

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. World Health Organization Global Hepatitis Report 2017 (World Health Organization 2017).

2. World Health Organizatioin Hepatitis C (2020); https://www.who.int/news-room/fact-sheets/detail/hepatitis-c.

3. A cross-species view on viruses

4. Decoding type I and III interferon signalling during viral infection

5. How host genetics dictates successful viral zoonosis

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