Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

Author:

Liu Yufeng1ORCID,Cheng Yuan1ORCID,Zhang He2ORCID,Zhou Min1,Yu Yijun3ORCID,Lin Shichao1ORCID,Jiang Bo4,Zhao Xiaozhi4,Miao Leiying3ORCID,Wei Chuan-Wan5,Liu Quanyi6,Lin Ying-Wu5ORCID,Du Yan6ORCID,Butch Christopher J.1ORCID,Wei Hui178ORCID

Affiliation:

1. Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.

2. Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.

3. Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.

4. Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu 210008 China.

5. Laboratory of Protein Structure and Function, School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China.

6. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China.

7. Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210093, China.

8. State Key Laboratory of Analytical Chemistry for Life Science and State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, Jiangsu 210023, China.

Abstract

We designed a cascade nanozyme with both superoxide dismutase– and catalase-mimicking activities for anti-inflammation therapy.

Funder

National Natural Science Foundation of China

National Natural Science Foundation of Jiangsu Province

Fundamental Research Funds for the Central Universities

PAPD program

Open Funds of the State Key Laboratory of Analytical Chemistry for Life Science

Open Funds of the State Key Laboratory of Coordination Chemistry

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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