A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis

Author:

Qin Lin1ORCID,Cao Jun23ORCID,Shao Kun4ORCID,Tong Fan1ORCID,Yang Zhihang1ORCID,Lei Ting1ORCID,Wang Yazhen1ORCID,Hu Chuan1ORCID,Umeshappa Channakeshava Sokke5ORCID,Gao Huile1ORCID,Peppas Nicholas A.3678ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

2. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.

3. Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.

4. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.

5. Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

6. Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA.

7. Institute for Biomaterials, Drug Delivery and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, USA.

8. Department of Surgery and Perioperative Care, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.

Abstract

In situ vaccine–based combinatorial therapy induced potent tumor-specific immunity against tumor recurrence and metastasis.

Funder

National Natural Science Foundation of China

111 Project

“Fundamentals of Research Funds” for the Central Universities

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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