Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement—A new target for lupus treatment

Author:

Smith Nikaïa1234ORCID,Rodero Mathieu P.123ORCID,Bekaddour Nassima123ORCID,Bondet Vincent56ORCID,Ruiz-Blanco Yasser B.7ORCID,Harms Mirja4,Mayer Benjamin8,Bader-Meunier Brigitte391011,Quartier Pierre3910,Bodemer Christine3912,Baudouin Véronique13,Dieudonné Yannick141516,Kirchhoff Frank4ORCID,Sanchez Garcia Elsa7ORCID,Charbit Bruno17ORCID,Leboulanger Nicolas318ORCID,Jahrsdörfer Bernd19,Richard Yolande32021ORCID,Korganow Anne-Sophie141516,Münch Jan4ORCID,Nisole Sébastien22ORCID,Duffy Darragh5617ORCID,Herbeuval Jean-Philippe123ORCID

Affiliation:

1. CNRS UMR-8601, CICB, 45 rue des Saints-Pères, 75006 Paris, France.

2. Team Chemistry & Biology, Modeling & Immunology for Therapy, CBMIT, Paris, France.

3. Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

4. Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.

5. Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France.

6. INSERM U1223, Paris, France.

7. Computational Biochemistry and Center of Medical Biotechnology, University of Duisburg-Essen, 45141 Essen, Germany.

8. Institute for Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.

9. Imagine Institute, Paris, France.

10. Paediatric Haematology-Immunology and Rheumatology Department, Hôpital Universitaire Necker, Assistance Publique-Hôpitaux de Paris, Paris, France.

11. INSERM UMR 1163, Laboratory of Immunogenetics of Paediatric Autoimmunity, Paris, France.

12. Department of Paediatric Dermatology, Reference Centre for Rare Skin Disorders (MAGEC), Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.

13. Hôpital Universitaire Robert Debré, Néphrologie pédiatrique, Paris, France.

14. CNRS UPR 3572 “Immunopathology and Therapeutic Chemistry”/Laboratory of Excellence Médalis, Institute of Molecular and Cellular Biology (IBMC), Strasbourg, France.

15. Department of Clinical Immunology and Internal Medicine, National Reference Center for Rare Autoimmune Diseases, University Hospital, Strasbourg, France.

16. UFR Medicine, University of Strasbourg, Strasbourg, France.

17. Centre for Translational Research, Institut Pasteur, Paris, France.

18. Pediatric Otolaryngology Department, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.

19. Institute of Transfusion Medicine and Immunogenetics (IKT) Ulm, Helmholtzstr. 10, 89081 Ulm, Germany.

20. INSERM U1016, Institut Cochin, Paris, France.

21. CNRS UMR 8104, Paris, France.

22. IRIM, Université de Montpellier, CNRS UMR, 9004 Montpellier, France.

Abstract

CXCR4 engagement by amines leads to the control of IFN signaling in pDCs and opens new therapeutic perspectives in Lupus patients.

Funder

Deutsche Forschungsgemeinschaft

Agence Nationale de la Recherche

EMBO

Agence Nationale de Recherches sur le Sida et les Hepatites Virales

SATT IdfInnov

BSD grant

Boehringer-Ingelheim Foundation

EU-funded

Start up funding program “Baustein” of the Medical Faculty of Ulm University

Labex EpiGenMed, an « Investissements d’avenir » program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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