Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor-Reference-Cited by-同舟云学术

Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor

Published:2021-06-04 Issue:23 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wen Tianlei¹^ORCID,Wang Ziyu¹,Chen Xiaozhe¹,Ren Yue¹^ORCID,Lu Xuhang¹^ORCID,Xing Yangfei²^ORCID,Lu Jing¹^ORCID,Chang Shenghai³⁴^ORCID,Zhang Xing³⁴^ORCID,Shen Yuequan¹⁵^ORCID,Yang Xue¹^ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300350, China.

2. State Key Laboratory of Medical Genomics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200025, China.

3. Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

4. Center of Cryo-Electron Microscopy, Zhejiang University School of Medicine, Hangzhou, China.

5. Synergetic Innovation Center of Chemical Science and Engineering, Tianjin 300071, China.

Abstract

Multiple structures of full-length calcium-sensing receptors reveal the mechanism of activation and allosteric modulation.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

National Key Research and Development Program of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference65 articles.

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4. The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases

5. A Familial Syndrome of Hypocalcemia with Hypercalciuria Due to Mutations in the Calcium-Sensing Receptor

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