Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7–driven B lymphopoiesis-Reference-Cited by-同舟云学术

Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7–driven B lymphopoiesis

Published:2018-01-05 Issue:1 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zeng Hu¹^ORCID,Yu Mei²,Tan Haiyan³⁴,Li Yuxin³⁴^ORCID,Su Wei¹⁵,Shi Hao¹^ORCID,Dhungana Yogesh¹,Guy Cliff¹^ORCID,Neale Geoffrey⁶^ORCID,Cloer Caryn¹,Peng Junmin³⁴^ORCID,Wang Demin²^ORCID,Chi Hongbo¹^ORCID

Affiliation:

1. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

2. Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA.

3. Departments of Structural Biology and Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

4. St. Jude Proteomics Facility, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

5. Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

6. Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

Abstract

PTEN-PI3K and IL-7R–mTORC1–Myc are two discrete signaling axes driving B cell development.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference98 articles.

1. Transcriptional Control of Early T and B Cell Developmental Choices

2. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF;Kikuchi K.;J. Exp. Med.,2005

3. Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling;Clark M. R.;Nat. Rev. Immunol.,2014

4. IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection;Sereti I.;Blood,2009

5. Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy

Cited by 36 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness;2024-03-01

2. B-Cell Metabolism;Molecular Biology of B Cells;2024

3. Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression;Genes;2023-10-17

4. IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion;Blood;2023-09-28

5. ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development;Frontiers in Immunology;2023-07-07