A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease

Author:

Ashton Nicholas J.1234,Nevado-Holgado Alejo J.5ORCID,Barber Imelda S.5,Lynham Steven6ORCID,Gupta Veer789,Chatterjee Pratishtha71011,Goozee Kathryn10111213ORCID,Hone Eugene78ORCID,Pedrini Steve78ORCID,Blennow Kaj314ORCID,Schöll Michael34ORCID,Zetterberg Henrik3141516,Ellis Kathryn A.17,Bush Ashley I.818ORCID,Rowe Christopher C.19,Villemagne Victor L.19ORCID,Ames David1720,Masters Colin L.18ORCID,Aarsland Dag1221ORCID,Powell John12ORCID,Lovestone Simon5,Martins Ralph781011ORCID,Hye Abdul12ORCID

Affiliation:

1. King’s College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute, London, UK.

2. NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK.

3. Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

4. Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.

5. Department of Psychiatry, University of Oxford, Oxford, UK.

6. Proteomics Core Facility, James Black Centre, King’s College, London, UK.

7. School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia.

8. Cooperative Research Centre for Mental Health, Carlton South, VIC, Australia.

9. School of Medicine, Faculty of Health, Deakin University, 3220 VIC, Australia.

10. KaRa Institute of Neurological Diseases, Macquarie Park, NSW, Australia.

11. Department of Biomedical Sciences, Macquarie University, 2109, NSW, Australia.

12. Clinical Research Department, Anglicare, Sydney, NSW, Australia.

13. School of Psychiatry and Clinical Neurosciences, University of Western Australia, WA, Australia.

14. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

15. Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.

16. UK Dementia Research Institute at UCL, London, UK.

17. Academic Unit for Psychiatry of Old Age, St. George’s Hospital, University of Melbourne, VIC, Australia.

18. The Florey Institute, University of Melbourne, VIC, Australia.

19. Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, Australia.

20. National Ageing Research Institute, Parkville, VIC, Australia.

21. Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.

Abstract

The untargeted discovery and replication of a blood protein panel shows promise for predicting preclinical Alzheimer’s disease.

Funder

Rosetrees Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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