Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

Author:

Zuo Yu1ORCID,Estes Shanea K.1,Ali Ramadan A.1,Gandhi Alex A.1,Yalavarthi Srilakshmi1,Shi Hui12ORCID,Sule Gautam1,Gockman Kelsey1,Madison Jacqueline A.1ORCID,Zuo Melanie3,Yadav Vinita4,Wang Jintao5,Woodard Wrenn6,Lezak Sean P.6,Lugogo Njira L.7,Smith Stephanie A.8ORCID,Morrissey James H.8ORCID,Kanthi Yogendra45ORCID,Knight Jason S.1ORCID

Affiliation:

1. Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

2. Division of Rheumatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3. Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

4. Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

5. Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.

6. Michigan Clinical Research Unit, University of Michigan, Ann Arbor, MI 48109, USA.

7. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

8. Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Some patients with severe COVID-19 develop prothrombotic autoantibodies that are similar to antiphospholipid antibodies found in autoimmune diseases.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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