Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis-Reference-Cited by-同舟云学术

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

Published:2018-08-03 Issue:26 Volume:3 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Rathkey Joseph K.¹,Zhao Junjie²,Liu Zhonghua¹,Chen Yinghua³^ORCID,Yang Jie¹³,Kondolf Hannah C.¹^ORCID,Benson Bryan L.¹^ORCID,Chirieleison Steven M.¹^ORCID,Huang Alex Y.¹⁴^ORCID,Dubyak George R.³^ORCID,Xiao Tsan S.¹^ORCID,Li Xiaoxia²^ORCID,Abbott Derek W.¹^ORCID

Affiliation:

1. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

2. Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

3. Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

4. Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Abstract

Necrosulfonamide inhibits pyroptosis through direct inhibition of gasdermin D.

Funder

National Institutes of Health

Harrington Discovery Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference29 articles.

1. The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process

2. MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

3. Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

4. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

5. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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