IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent-Reference-Cited by-同舟云学术

IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent

Published:2021-05-28 Issue:59 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Hardman Clare S.¹^ORCID,Chen Yi-Ling¹^ORCID,Salimi Maryam¹,Nahler Janina¹^ORCID,Corridoni Daniele¹^ORCID,Jagielowicz Marta¹^ORCID,Fonseka Chathuranga L.¹^ORCID,Johnson David²^ORCID,Repapi Emmanouela³^ORCID,Cousins David J.⁴⁵^ORCID,Barlow Jillian L.⁶,McKenzie Andrew N. J.⁶^ORCID,Simmons Alison¹^ORCID,Ogg Graham¹^ORCID

Affiliation:

1. MRC Human Immunology Unit, NIHR Biomedical Research Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

2. Department of Plastic and Reconstructive Surgery, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.

3. MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Oxford, UK.

4. Department of Infection, Immunity and Inflammation, NIHR Leicester Respiratory Biomedical Research Unit, University of Leicester, Leicester, UK.

5. MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King’s College London, London, UK.

6. MRC Laboratory of Molecular Biology, Cambridge, UK.

Abstract

Human ILC2 express NOD2 and secrete IL-6 in response to bacterial ligands.

Funder

Wellcome

Medical Research Council

NIHR Oxford Biomedical Research Centre

NIHR Leicester Biomedical Research Centre

Crohn’s and Colitis UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference90 articles.

1. Innate Lymphoid Cell Development: A T Cell Perspective

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4. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

5. Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

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